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ea0029p824 | Endocrine tumours and neoplasia | ICEECE2012

Effects of mitotane on gene expression in the NCI-H295R cell line

Zsippai A. , Szabo D. , Tombol Z. , Szabo P. , Eder K. , Patocs A. , Toth S. , Falus A. , Racz K. , Igaz P.

Background: The adrenolytic agent mitotane is widely used in the adjuvant treatment of adrenocortical cancer, but its mechanism of action including potential effects on mRNA expression is poorly elucidated.Objective: To examine mitotane-induced mRNA expression changes in the H295R adrenocortical cancer cell line.Methods: Various concentrations of mitotane in different treatment periods (24120 h) have been tested in cell viabi...

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ea0026p364 | Adrenal medulla | ECE2011

Unusual mutation spectrum in Hungarian patients with apparently sporadic pheochromocytomas

Lendvai N L , Szabo I S , Toth M T , Forizs E F , Solyom E S , Beko G B , Igaz P I , Racz K R , Patocs A P

Background: Pheochromocytomas (Pheo) and paragangliomas (PGL) are rare, mostly benign tumors. Most of these tumors are sporadic but a significant percentage can be found as components of hereditary tumor syndromes caused by germline mutations of the VHL, RET, NF1, SDHD, SDHC, SDHB and the recently identified SDHAF2 genes. Germline mutations of these genes can be also found in several cases with apparently sporadic Pheo/PGL.<...

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Endocrine Abstracts

Effects of mitotane on gene expression in the NCI-H295R cell line

Unusual mutation spectrum in Hungarian patients with apparently sporadic pheochromocytomas

BiosciAbstracts